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Updated: Feb 4, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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在PROTAC设计中,阿里利丁-二基架作为DCAF11的E3连接体起作用

Jinyi Liang1, Yuyang Liu1, Man Zhao1,2

  • 1Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.

Journal of medicinal chemistry
|February 2, 2026
PubMed
概括

研究人员开发了一种新型的阿里利丁 - 二二支架,作为DCAF11连接体,用于蛋白质溶解向奇默体 (PROTACs). 这导致LGF308,一个强大的BRD4降解剂,展示了脚手架.

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