缩短的高剂量息性放射治疗肺癌 (SHiP-Rt):单臂,多中心,II期研究的协议
Raj Kumar Shrimali1, Ellanna Griffin2, Vicky Sturgess3
1Institute for Precision Diagnostic & Translational Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
BMJ open
|February 2, 2026
概括
这项研究使用现代技术评估了非小细胞肺癌 (NSCLC) 的新型,较短的息性放射治疗 (RT) 计划. 目的是评估这种加速RT方案的安全性和可行性.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 临床试验 临床试验
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 的存活率通过全身疗法得到改善.
- 目前的息性放射治疗 (RT) 方案是基于20世纪90年代过时的技术.
- 当代RT使用先进的技术,如4D-CT和VMAT,以提高精度和降低毒性.
研究的目的:
- 评估缩短高剂量息性RT疗法对NSCLC的安全性和可行性.
- 通过使用当代RT的规划和交付来评估新的剂量分数表.
- 探索潜在的好处,包括毒性概况和成本节省.
主要方法:
- 这是一项单臂,多中心的II期研究,招募了37名晚期NSCLC患者.
- 实施低分化加速息性RT疗法: 30 Gy分为6个交替一天的部分.
- 使用严格的正常组织剂量限制和由RTTQA支持的质量保证.
主要成果:
- 主要目标:评估拟议剂量分割的安全性.
- 二级目标:评估毒性,患者报告的结果,进展时间,可行性和NHS成本节省.
- 研究的注册:NCT06483308.8.研究的注册
结论:
- 这项研究旨在确定NSCLC加速息性RT计划的安全性和可行性.
- 结果将为潜在的III期随机对照试验提供信息,以评估疗效.
- 结果将传播给参与者,并在同行评审期刊上发表.
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