类风湿性关节炎患者的远程监控工具:FACIT疲劳和HAQ
Elena Grau García1, Pablo Francisco Muñoz Rodriguez2, Hikmat Charia1
1Rheumatology Research Group, Instituto de Investigaciones Sanitarias La Fe, Valencia, Spain.
Reumatologia clinica
|February 2, 2026
概括
患者报告的结局 (PROs),如疼痛和疲劳,与类风湿性关节炎 (RA) 临床活动有显著的相关性. 更高的疲劳和残疾与停止治疗有关,这表明PROs有助于远程监测RA.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 患者报告的结果
背景情况:
- 类风湿性关节炎 (RA) 管理需要监测疾病活动.
- 患者报告的结果 (PROs) 提供了对患者体验的见解.
研究的目的:
- 研究RA患者的临床疾病活性与患者报告的结果 (疼痛,疲劳,残疾) 之间的关联.
- 评估PROs在监测RA疾病控制中的有用性.
主要方法:
- 预期观察性研究,随访3个月.
- 60名RA患者开始生物或JAK抑制剂治疗.
- 评估了PROs (FACIT-疲劳,HAQ,疼痛VAS) 和临床活动 (DAS28,DAS28-CRP,SDAI,CDAI).
主要成果:
- 在临床活动和疲劳,疼痛和残疾之间发现了显著的关联 (p<0.001).
- 增加的疲劳与更高的疼痛感知和疼痛关节数量相关 (p=0.002).
- 停止治疗的患者表现出更高的疲劳和残疾 (p=0.044,p=0.0013).
结论:
- 在RA中,PRO与临床活性有显著的关联.
- 在RA中,PRO可以成为远程监测和疾病管理的宝贵工具.
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