AoMbp1 与 AoSwi6 相互作用,并调节 Arthrobotrys oligospora 中的阴茎发育,应激耐受性,陷形态发生和病原性
Na Bai1, Hui Yuan2, Guiqiu Luo2
1State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory of Industrial Microbial Fermentation Engineering of Yunnan Province, and School of Life Sciences, Yunnan University, Kunming 650091, China; School of Life Sciences, Henan Institute of Science and Technology, Xinxiang 453003, China.
Pesticide biochemistry and physiology
|February 2, 2026
概括
APSES蛋白AoMbp1对于线虫捕捉真菌Arthrobotrys oligospora的发展至关重要. 它的失活严重损害菌根的生长,子的生产,和陷的形成,对于线虫掠食至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 分子生物学分子生物学
- 菌类遗传学 菌类遗传学
背景情况:
- APSES蛋白调节真菌的生长和发育.
- 像Arthrobotrys oligospora这样的阴虫捕捉真菌是研究专门结构的模型生物.
- 了解转录因子的作用是真菌生物学的关键.
研究的目的:
- 为了功能性地表征AoMbp1,APSES类型的转录因子在A. oligospora.
- 阐明AoMbp1在菌株发育,结合和陷形成中的作用.
- 确定涉及AoMbp的交互伙伴和监管途径1.1.
主要方法:
- 基因失活 (突变基因的产生).
- 对生长,发育和应激反应的表型分析.
- RNA测序,DNA亲和力净化测序,和酵母分子相互作用的两杂交试验.
主要成果:
- AoMbp1的失活导致菌根生长的严重缺陷,分离的增加,脂质的积累和核数的减少.
- 突变者表现出受损的基和子生产,异常的子形态,以及对透应激的敏感性增加.
- 陷的形成和线虫的捕食被显著减少,陷失去了它们的3D结构.
- AoMbp1与AoSwi6相互作用,它们一起调节细胞循环,化,脂质代谢和DNA修复.
结论:
- 在A. oligospora中,AoMbp1对于正常的菌株发育,化和脂质代谢至关重要.
- AoMbp1在线虫捕获结构的形态发生中起着至关重要的作用.
- AoMbp1-AoSwi6复合体参与了基本的细胞过程,包括细胞周期控制和DNA维护.
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