关联皮层中的关键动力学预测了典型发育儿童的更高智力
Gianina Cristian1,2,3,4,5, Cece C Kooper6,7, Arthur-Ervin Avramiea3,8
1Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands k.linkenkaerhansen@vu.nl gianina.cristian@radboudumc.nl.
概括
靠近临界度的大脑动态,用功能激发/抑制比 (fE/I) 来衡量,与儿童和青少年的智力相关. 更高的智力与更接近关联皮层关键点的FE/I值有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 发育神经科学的发展神经科学.
背景情况:
- 神经网络模型表明,关键动态优化信息处理.
- 与激发/抑制 (E/I) 不平衡相关的大脑关键性的干扰与神经病理学有关.
- 在发展中的人类中,将关键大脑动态与认知联系起来的经验证据是有限的.
研究的目的:
- 在健康的儿童和青少年中研究关键大脑动态和智力之间的关系.
- 检查功能激发/抑制比 (fE/I) 和1/f无周期指数如何与不同大脑网络的智商相关.
- 探索年龄对这些关系的影响.
主要方法:
- 在128名儿童 (6-19岁) 中记录了眼睛打开的休息电脑脑图 (EEG).
- 使用α频段fE/I和功率谱的1/f无周期指数量化近临界的大脑动态.
- 在七个Yeo功能大脑网络中,与fE/I和1/f指数相关的模拟智商 (IQ).
主要成果:
- 在高阶关联皮层中发现了FE/I,1/f指数和智商之间的显著相关性,而不是感觉运动皮层.
- 高智商儿童在协会皮层中表现出FE/I比率接近理论临界值1.
- 关联传感运动网络层次结构调节了1/f指数和智商之间的关系,影响在整个层次结构中下降.
- 年龄和网络等级调节了fE/I-IQ关联,梯度在青少年中最明显.
结论:
- 关联网络内的关键性敏感生物标志物的个体变异与年龄依赖的智商差异有关.
- 在皮层层次结构中对关键动态的发育调制可能支持高效的认知处理.
- 这些发现与计算模型相一致,将大脑的关键性与最佳功能联系起来,并可能有助于理解大脑疾病.
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