超直流刺激在超急性缺血性中风 (DICAST-SF试验) 中是安全的和可行的
Matej Slovak1, David Kemlink1, Pavel Dusek1
1Department of Neurology and Center for Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic.
概括
对急性缺血性中风患者来说,阴道跨直流刺激 (C-tDCS) 是安全的和可行的. 这种神经保护方法表现出良好的耐受性,支持进一步对中风治疗的试验.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 医疗器械 医疗器械
背景情况:
- 缺血性中风在超急性阶段需要紧急的神经保护.
- 阴极跨直流刺激 (C-tDCS) 是一种潜在的神经保护性干预.
- 评估C-tDCS在中风患者中可挽救的半阴影是至关重要的.
研究的目的:
- 评估C-tDCS的安全性,耐受性和可行性.
- 探索C-tDCS在急性缺血性中风中的潜在疗效.
- 在剂量升级试验中确定C-tDCS参数.
主要方法:
- 一个双盲的,随机的,模拟控制的,剂量升级试验 (DICAST-SF).
- 包括中风患者的内动脉/中脑动脉封闭,在24小时内,和可挽救的半阴影.
- 在受影响的初级运动皮质上施加C-tDCS,分六种剂量级别.
主要成果:
- 在活跃的C-tDCS组中没有出现症状性内出血 (SICH).
- C-tDCS耐受性良好且可行,随机化至刺激的中位数开始时间为8分钟.
- 无症状内出血 (AICH) 和其他不良事件在活体和虚假组之间是可比的.
结论:
- 超急性缺血性中风的C-tDCS是一种安全,耐受性良好的,可行的治疗方法.
- 这些发现支持在更大的中风疗效临床试验中进一步调查C-tDCS.
- 作为急性中风管理中的神经保护策略,C-tDCS显示出前景.
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