在LPS诱导的早产中,IL-37减轻炎症效应和NLRP3炎症酶激活
Yue Yang1, Jingyi Wang1, Qiying Zhu2
1Department of Obstetrics, Maternal foetal Medicine Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830021, Xinjiang, China.
Scientific reports
|February 2, 2026
概括
互白素-37 (IL-37) 水平在早产 (PTB) 中降低. 在小鼠模型中,复合IL-37 (rhIL-37) 治疗减少了炎症和延迟PTB,显示出治疗潜力.
科学领域:
- 生殖生物学 生殖生物学
- 免疫学 免疫学 免疫学
- 分子医学是分子医学.
背景情况:
- 过早分娩 (PTB) 是一个主要的全球健康问题,带来了巨大的家庭和社会成本.
- 干白素-37 (IL-37) 和NLRP3炎症酶激活与PTB有关,但IL-37的直接作用和机制尚不清楚.
研究的目的:
- 为了研究IL-37在PTB中的表达.
- 确定重组IL-37 (rhIL-37) 在预防PTB方面的治疗潜力,并阐明其潜在机制.
主要方法:
- 从术期和早产妇女收集胎儿膜和胎盘组织,以分析IL-37的表达.
- 利用LPS诱导的小鼠模型来评估rhIL-37对早产,炎症性细胞因子和NLRP3炎症酶激活的影响.
- 在体外机理学研究中使用LPS诱导的人类热囊细胞HTR-8/Svneo.
主要成果:
- 在早产患者的胎儿膜中,IL-37 mRNA表达显著下调.
- 在小鼠中,rhil-37的使用延迟了LPS诱导的早产超过24小时.
- rhIL-37抑制了炎症性细胞因子释放 (IL-1β,IL-6,TNF-α) 并抑制了NF-κB/NLRP3炎症酶激活在体内和体外.
结论:
- 在PTB中,IL-37的调控下降,这表明它具有保护作用.
- rhIL-37显示出显著的抗炎作用,并通过NF-κB/NLRP3轴减少NLRP3炎症酶激活.
- rhIL-37作为一种用于预防PTB的新型治疗剂具有前景.
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