来自肠道微生物群的酸通过调解脂质代谢重编程来促进蜜蜂的系统免疫力
Jiaming Liu1, Yashuai Wu1, Zhenfang Li1
1State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.
Nature communications
|February 2, 2026
概括
蜜蜂肠道微生物群的代谢物丁酸盐可以增强免疫力. 丁酸盐通过重编程脂肪体代谢和调节前列腺素E2生物合成来恢复免疫能力.
科学领域:
- 昆虫免疫学 昆虫免疫学
- 微生物的新陈代谢
- 宿主-微生物相互作用
背景情况:
- 肠道微生物群对于昆虫的免疫启动至关重要,模仿脊椎动物获得的免疫力.
- 昆虫中肠道微生物群介导的远程免疫调节的机制尚不清楚.
研究的目的:
- 为了研究微生物代谢物在蜜蜂免疫代谢交叉的作用.
- 为了确定参与肠道微生物介导免疫原始化的关键代谢物.
主要方法:
- 使用无细菌和微生物群殖民的蜜蜂.
- 蜜蜂补充了丁酸盐,一种微生物代谢物.
- 分析了脂肪体的代谢重编程和前列腺素E2生物合成.
主要成果:
- 酸盐补充剂恢复了无菌蜜蜂的免疫能力.
- 丁酸盐通过G蛋白结合受体41和HDAC抑制激活了甘油脂和阿拉基酸代谢.
- 这种新陈代谢重编程调节了前列腺素E2,这对免疫激活至关重要.
结论:
- 丁酸盐是一种关键的微生物代谢物,协调蜂蜜中的免疫代谢交叉.
- 肠道微生物群与宿主相互作用驱动免疫和代谢系统的整合,通过像丁酸盐这样的代谢物.
相关概念视频
Overview of Lipid Metabolism
5.2K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
5.2K
Cell-mediated Immune Responses
84.1K
Overview
84.1K
What is the Immune System?
128.1K
Overview
128.1K
Cytotoxic T Cells-mediated Immune Response
7.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.5K
Lipid-derived Compounds in the Human Body
6.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.5K
What is Metabolism?
131.8K
Overview
131.8K


