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Updated: Feb 4, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Substrate Generation for Endonucleases of CRISPR/Cas Systems

Published on: September 8, 2012

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通过蛋白质语言模型定制CRISPR-Cas PAM特异性

Stephen Nayfach1, Aadyot Bhatnagar2, Andrey Novichkov2

  • 1Profluent Bio, Emeryville, CA, USA. snayfach@profluent.bio.

Nature biotechnology
|February 2, 2026
PubMed
概括

科学家们开发了Protein2PAM,这是一种深度学习模型,可以有效地为特定的DNA目标设计CRISPR-Cas变体. 这推动了基因组编辑的进步,克服了原空间体相邻的动图限制.

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