调查EndoFLIPTM作为病理性反流查工具的实用性 EndoFLIPTM作为GERD查工具的实用性
John W Keyloun1,2, Andrew Mertz1,3, Bonnie C Carney4
1Johns Hopkins Sibley Memorial Hospital, Washington, DC, USA.
Surgical endoscopy
|February 2, 2026
概括
内膜功能性膜成像探头 (EndoFLIPTM) 的测量,特别是DI50和DI60,可以预测GERD诊断的积极的BravoTM pH测试. 这一发现可能通过减少对某些患者的pH监测需求来简化诊断工作流程.
科学领域:
- 胃肠病学 胃肠病学
- 诊断成像 诊断成像 诊断成像
- 医疗器械技术 医疗器械技术
背景情况:
- 内膜功能性膜成像探头 (EndoFLIPTM) 越来越多地用于诊断胃食道逆流症 (GERD).
- 在BravoTM pH监测之前经常进行EndoFLIPTM,以排除被考虑进行抗逆流体手术的患者的运动障碍.
- 里昂共识2.0指南表明,洛杉矶 (LA) B级食道炎是GERD的诊断,可能避免pH测试.
研究的目的:
- 评估EndoFLIPTM测量是否可以独立预测积极的BravoTM pH监测结果.
- 在预测GERD时,评估特定延展性指数 (DI) 值的诊断准确性.
- 优化GERD的诊断途径,潜在地提高效率和降低成本.
主要方法:
- 一个单一中心对171名具有本地解剖学的成年患者进行了回顾性审查,他们接受了96小时的BravoTM pH监测和EndoFLIPTM.
- 阳性 (Bravo+) 和阴性 (Bravo-) pH监测结果的患者的比较.
- 用接收器操作特征 (ROC) 曲线分析来评估DI50,DI60和DI70值的诊断准确性.
主要成果:
- 洛杉矶 (LA) B级食道炎在Bravo+患者中更频繁 (7.8%与0%相比).
- 在Bravo+患者中,中位数DI60显著更高 (4.0对3.4mm2/mmHg).
- DI50和DI60在Bravo+结果 (AUC为0.67和0.65) 中显示出良好的区别,在整体队列中具有高特异性 (94%). DI70在女性中表现最好 (AUC为0.69).
结论:
- DI60值与积极的BravoTM pH测试有显著的相关性.
- DI50和DI60在整体队列和男性中表现出强大的诊断性能.
- DI70显示出优越的诊断价值,特别是在女性患者中.
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