VGLL4调节帕内斯细胞并维持肠道平衡
Haoen Zhang1,2, Zuoyun Wang3, Xiaodong Wang4
1Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, China.
EMBO reports
|February 2, 2026
概括
样家族4号成员 (VGLL4) 对于肠道健康至关重要,调节帕内斯细胞并维持肠道平衡. 失去VGLL4会损害肠道屏障和微生物平衡.
科学领域:
- 胃肠病学 胃肠病学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 帕内斯细胞对于小肠干细胞位维护和免疫常态稳定至关重要.
- 它们分泌的利基因子和抗菌 (AMP).
- VGLL4在肠道平衡和帕内特细胞调节中的作用尚未被探索.
研究的目的:
- 为了调查Vestigial-like家族成员4 (VGLL4) 在维持小肠平衡中的作用.
- 为了阐明VGLL4在Paneth细胞中的调节功能.
主要方法:
- 对VGLL4表达反应对照射和DSS诱导的大肠炎的分析.
- 在VGLL4缺陷模型中评估帕内斯细胞数量和AMP的产生.
- 研究VGLL4与TEAD4,ATOH1和TCF4.4的分子相互作用.
- 检查肠道微生物群的组成.
主要成果:
- 在肠道损伤模型和人类大肠炎中,VGLL4的表达是下调的.
- 失去VGLL4会减少帕内斯细胞数量,降低AMPs的产生,并导致肠道功能失调.
- VGLL4与TEAD4/ATOH1相互作用,通过GFI1.1促进帕内斯细胞的分化.
- VGLL4与TEAD4/TCF4相互作用,诱导防御素的表达,维持微生物群.
结论:
- VGLL4在维持小肠平衡中发挥着关键作用.
- VGLL4调节了帕内斯细胞的分化和功能.
- VGLL4对于维持肠道微生物群组成和再生能力至关重要.
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