卢芬双载体纳米配方:通过β-环极德八甲酸和尿素-甲树脂控制释放和全身转移
Zhiping Liu1, Jiansheng Li1, Yanmin Huang1
1Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, PR China.
Langmuir : the ACS journal of surfaces and colloids
|February 2, 2026
概括
一种新型的双封装氨酸纳米配方 (LF@β-CDs/UF) 显著提高了杀虫剂的有效性和环境安全性. 与传统方法相比,这种先进的配方改善了害虫控制,并减少了生态毒性.
科学领域:
- 农业科学 农业科学
- 材料科学 材料科学 材料科学
- 环境科学 环境科学
背景情况:
- 传统的杀虫剂配方往往由于利用效率低和环境风险高而受到影响.
- 卢芬 (LF) 是一种有效的杀虫剂,但它的稳定性和传递性可以得到改善.
- 开发先进的纳米配方对于可持续的害虫管理至关重要.
研究的目的:
- 开发和表征一种双载体纳米制剂的lufenuron使用β-cyclodextrin octadecanoate和尿素甲树脂 (LF@β-CDs/UF).
- 为了评估LF@β-CDs/UF纳米配方的受控释放,光解稳定性,杀虫活性和环境安全性.
- 展示双载体技术的优势,以提高农药的输送效率和减少生态影响.
主要方法:
- 在β-环氧德克斯二甲酸和尿素甲树脂中进行双重封装lufenuron.
- 在受控的温度和pH条件下评估卢芬释放动力学.
- 与单载体和微乳液配方相比,光解稳定性的评估 (t50).
- 生物测试以确定杀虫剂对Spodoptera litura的有效性.
- 植物系统转移研究.
- 生物安全评估包括大米种子发芽和斑马鱼急性毒性 (LC50).
主要成果:
- 该LF@β-CDs/UF纳米配方表现出324小时的延长释放周期,比LF@β-CDs长1.5倍.
- 光解半衰期延长了1.6倍 (与LF@β-CD相比) 和9.3倍 (与LF微乳液相比).
- 在6.25 mg/L的剂量下,LF@β-CDs/UF实现了73.33%的对Spodoptera litura的死亡率,明显高于对照组.
- 米种子发芽率由LF@β-CDs/UF种子浸泡改善,从40.7%提高到71.3%.
- 斑马鱼的LC50增加了4.4倍,表明急性毒性减少.
结论:
- 与β-环氧德克斯二甲酸和尿素甲树脂的双封装为卢芬的输送产生了协同效应.
- 在植物中,LF@β-CDs/UF纳米配方提供了增强的稳定性,延长的疗效和改进的系统转位.
- 这项技术显著降低了生态毒性,为传统杀虫剂配方提供了更环保,更有效的替代方案.
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