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口腔状细胞癌的口腔细菌微生物群变化:系统性审查和元分析
Qixuan Cao1, Yue Yang2,3, Shuang Bai4,5
1College of Medicine, Nankai University, Tianjin, 300071, China.
BMC oral health
|February 3, 2026
概括
这项研究发现,口腔状细胞癌 (OSCC) 中明显的口腔细菌变化. 关键发现显示,有害细菌 (如菌) 的增加和有益细菌的减少,这表明OSCC检测的潜在生物标志物.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 口腔细菌微生物群在保持口腔健康方面发挥着至关重要的作用.
- 微生物群落的不平衡,即失生症,越来越多地与包括癌症在内的各种疾病有关.
- 了解口腔状细胞癌 (OSCC) 的特定微生物变化对于早期检测和治疗策略至关重要.
研究的目的:
- 系统地评估与口腔状细胞癌 (OSCC) 相关的口腔细菌微生物群的组成变化.
- 利用下一代测序 (NGS) 数据对OSCC中微生物变化的全面分析.
- 通过元分析识别OSCC的潜在微生物生物标志物.
主要方法:
- 使用PRISMA指南对病例控制研究进行系统审查和元分析.
- 在PubMed,Web of Science和Embase进行文献搜索,截至2025年10月25日.
- 包括比较OSCC患者口腔细菌微生物群和使用NGS的健康对照的研究;通过纽卡斯尔-太华尺度 (NOS) 和ROBINS-I进行质量评估;使用Stata软件对相对丰度进行元分析.
主要成果:
- 纳入了16个研究,共有1608名参与者 (813名OSCC,795名对照);所有研究都具有中等到高质量.
- 在类层面上,OSCC组的Actinobacteria显著较低 (SMD = -0.85) 和Fusobacteria (SMD = 0.61) 显著较高.
- 在Fusobacterium,Capnocytophaga,Peptostreptococcus,Alloprevotella,Parvimonas和Dialister的显著丰富;在属层面上减少了Streptococcus,Haemophilus,Rothia,Veillonella,Actinomyces和Leptotrichia的数量.
结论:
- 在OSCC中鉴定出一种独特的口腔细菌微生物群特征,其特征是失生症.
- 这种特征包括促进炎症/致病性属的丰富 (例如,Fusobacterium) 和与健康相关的共生菌 (例如,Streptococcus) 的枯竭.
- 这些特定的微生物种群代表了OSCC的潜在生物标志物,需要进一步调查.
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