良性前列腺增生症中的肠前列腺轴:对微生物失生症和致病机制的系统审查
Yuanzhao Xu1,2, Lingyue An2, Jiling Xie3
1Graduate School of Medicine, Zunyi Medical University, Zunyi, Guizhou, 563006, China.
BMC urology
|February 3, 2026
概括
肠道微生物群的变化,包括Firmicutes/Bacteroidetes比率的增加,与良性前列腺增生 (BPH) 的发展有关. 这些变化和肠道屏障功能障碍可能为BPH提供新的诊断和治疗点.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群失生症越来越多地与良性前列腺激增症 (BPH) 的病原发生有关.
- 在BPH患者中,特定的肠道微生物概况仍然不完全理解.
研究的目的:
- 系统地审查和分析有关肠道微生物群和BPH之间的关系的现有研究.
- 确定与BPH发展相关的关键微生物和宿主因素.
主要方法:
- 在PubMed,MEDLINE和Web of Science数据库中进行了系统的文献搜索.
- 包括临床和临床前研究,调查BPH的肠道微生物群.
- 分析了10项临床前和6项临床研究的数据,涉及413名BPH患者和338名对照.
主要成果:
- 与对照人群相比,在BPH患者中观察到肠道微生物β-多样性的显著差异.
- 鉴定出F/B比率 (Firmicutes/Bacteroidetes) 的升高是BPH病理学的标志.
- 在Prevotella,Ruminococcus和Lactobacillus丰度的变化,以及炎症标记物 (IL-6,IL-18) 和肠道屏障蛋白 (紧结蛋白-1,Claudin-1),与BPH有关.
结论:
- 肠道微生物群的变化,包括增加F/B比率和减少Lactobacillus,有助于BPH的发病.
- 炎症指标和肠道屏障功能障碍标志物与BPH发展有关.
- 这些微生物和宿主因素代表了BPH的潜在诊断生物标志物和治疗点.
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