瘤激活的双代谢纳米调节器转换了耐受性瘤控制,并释放了全身免疫反应
Xiaorong Kou1, Xue Wu2, Tao He1
1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Journal of nanobiotechnology
|February 3, 2026
概括
这项研究介绍了RAISE,它是一种激发瘤细胞死亡并增强免疫反应的纳米调节器. RAISE有效地促进长期的全身抗瘤免疫力,改善癌症免疫治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
背景情况:
- 压力后的免疫抑制可以暂时克服,提供免疫治疗潜力.
- 治疗方法必须将局部信号转化为持续的全身抗瘤反应,以避免免疫耐受性.
研究的目的:
- 开发一种瘤激活纳米调节器 (RAISE),以诱导瘤细胞死亡并支持树突细胞 (DC) 功能.
- 为了协同地从耐受性瘤控制转向强大的抗瘤免疫.
主要方法:
- 构建了一个对瘤酶和细胞内谷氨 (GSH) 反应的双代谢纳米调节器 (RAISE).
- RAISE分解以释放药物,诱导免疫细胞死亡,并缓解免疫抑制.
- RAISE促进了CD103+DCs,增强了抗原交叉呈现,并阻断了胺二二氧化酶 (IDO).
主要成果:
- RAISE诱导了广泛的瘤细胞死亡,并缓解了免疫抑制.
- 提高补充内CD103+DCs,放大T细胞激活.
- RAISE对IDO的阻断恢复了瘤对T细胞免疫的敏感性,防止了耐受性,并诱导了免疫记忆.
- RAISE证明了有效的瘤控制,与抗PD-1一起,抑制了肺转移,并产生了全身免疫反应.
结论:
- RAISE有效地触发了一连串的免疫激活,克服耐受性并建立持久的免疫记忆.
- 在癌症免疫治疗中,RAISE有望增强长期的全身抗瘤免疫力.
相关概念视频
Humoral Immune Responses
83.9K
Overview
83.9K
Control Systems
1.9K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
At the heart...
1.9K
Control Systems: Applications
1.2K
Electrical engineering plays a pivotal role in our daily lives, with control systems at the heart of many applications, from home appliances to sophisticated space shuttles. Control systems manage and regulate the behavior of devices and processes, ensuring they function safely, correctly, and efficiently.
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
1.2K
Feedback control systems
722
Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
722
Tumor Immunotherapy
1.9K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K


