一个系统的审查和对帕佐帕尼布疗效和对沙尔科马的不良影响的元分析
Fernanda Picozzi1, Alessandro Ottaiano2, Antonella Lucia Marretta3
1Sarcoma and Rare Tumors Unit, Istituto Nazionale Tumori, IRCCS Fondazione "G. Pascale", 80131, Naples, Italy.
Journal of translational medicine
|February 3, 2026
概括
帕佐帕尼布在瘤治疗中显示出组织学特异性的疗效,并具有可控的副作用. 它与其他非安慰剂治疗不逊色,这表明需要对晚期肉瘤进行进一步的比较研究.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 帕佐帕尼布是一种用于各种癌症的多向氨酸激酶抑制剂.
- 转移性非脂肪细胞软组织肉瘤是用pazopanib治疗的一种恶性瘤.
研究的目的:
- 评估帕佐帕尼布单一治疗在肉瘤治疗中的疗效和毒性.
- 为了比较pazopanib与非安慰剂干预措施的先进的肉瘤.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在PubMed/MEDLINE和Scopus/ELSEVIER (2009-2025) 中进行了搜索.
- 使用MINORS,纽卡斯尔-太华尺度和RoB2评估研究质量;对无进展生存 (PFS) 和总生存 (OS) 的元分析.
主要成果:
- 包括40项具有可变质量的研究.
- 最高的客观应答率 (ORR) 在瘤 (37.0%) 和膜软部肉瘤 (35.5%) 中.
- 常见的毒性:高血压,肝脏异常,疲劳;PFS和OS的聚合危险比率 (HR) 没有显示出与非安慰剂治疗相比的显著优势.
结论:
- 帕佐帕尼布在肉瘤中表现出组织学特异性疗效和可管理的毒性概况.
- 帕佐帕尼布对非安慰剂干预措施没有劣势.
- 需要进一步的比较研究来确定pazopanib在先进的肉瘤治疗中的作用.
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