循环无细胞DNA作为免疫功能和艾滋病毒感染患者疾病进展的生物标志物:一个横截面观察性研究
Lu Cheng1, Haokun Gao2, Meixin Fang3
1Clinical Laboratory of Zhejiang Hospital, Hangzhou, 310007, China.
European journal of medical research
|February 3, 2026
概括
循环无细胞DNA (ccfDNA) 水平与HIV-1患者的免疫功能障碍相关. 这种生物标志物显示出监测HIV-1感染者免疫状况和疾病进展的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物标志物发现发现
背景情况:
- 人类免疫缺陷病毒1型 (HIV-1) 感染导致免疫缺陷,主要是通过CD4+T细胞枯竭.
- 监测免疫功能和疾病进展对于控制HIV-1病毒至关重要.
研究的目的:
- 探索循环无细胞DNA (ccfDNA) 作为HIV-1感染个体免疫状况和疾病进展的潜在生物标志物.
- 评估ccfDNA水平与HIV-1患者免疫/病毒学参数之间的关系.
主要方法:
- 一项涉及79名接受抗逆转录病毒治疗的HIV-1患者和35名对照者的横截面研究.
- 测量ccfDNA水平,CD4+T细胞计数,免疫激活/亡标志物和病毒载荷.
- 进行了相关性和接收器运行特征 (ROC) 曲线分析.
主要成果:
- ccfDNA与CD4+T细胞计数呈负相关性,与病毒载量呈正相关性.
- ccfDNA水平与T细胞免疫激活和亡标记有显著的关联.
- ROC分析表明ccfDNA作为监测HIV-1患者的补充生物标志物的潜力,曲线下的面积为0.799.
结论:
- ccfDNA水平与HIV-1感染个体的免疫功能障碍密切相关.
- 在HIV-1管理中,ccfDNA可以作为一种有价值的补充生物标志物,用于监测免疫状态和疾病进展.
相关概念视频
Cross-Sectional Research
12.5K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.5K
What is the Immune System?
128.1K
Overview
128.1K
Finding Volume Using Cross-Sectional Area
68
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
68
Profile Leveling and Cross Sections
1.6K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K
Observational Studies
11.1K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
Spinal Cord: Cross-sectional Anatomy
4.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.8K


