杂微生物群和宿主多器官相互作用的整合性分析,以确定胡羊的料转化效率
Xiaowei Jia1,2,3, Yuanxin Zhang1,2, Boya Tian1,2
1Ruminant Nutrition and Feed Engineering Technology Research Center, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Journal of animal science and biotechnology
|February 3, 2026
概括
低料转换比率 (FCR) 绵羊中的乳液微生物有效合成挥发性脂肪酸和氨基酸. 这提高了能量利用,促进了肝脏的葡萄糖生成,改善了肌肉生长和整体料效率.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 体微生物群显著影响反动物的料效率.
- 控制料转换效率 (FCE) 的宿主微生物相互作用尚未完全理解.
研究的目的:
- 通过与宿主器官的综合相互作用,研究 rumen 微生物如何塑造料转化效率 (FCE).
- 阐明在胡羊的料效率差异背后的机制.
主要方法:
- 综合的多体基因组学分析,结合体基因组学和宿主多器官转录基因组学.
- 选择具有不同料转换效率 (FCR) 现型 (低FCR与高FCR) 的胡羊.
- 对肠微生物组组成,功能和宿主基因表达在肝脏,肌肉和肠表皮中的比较分析.
主要成果:
- 低FCR的羊表现出增长和更高的反 propionate,其微生物组富含特定细菌 (Saccharofermentans,Succinivibrionaceae_UBA2804) 和氨基酸和 propionate 合成的功能途径.
- 在低FCR和高FCR羊之间观察到不同的碳水化合物活性酶和代谢概况.
- 主体转录组学揭示了肝脏特定的碳水化合物代谢和与微生物短链脂肪酸相关的葡萄糖生成途径的丰富,而肌肉显示了优化的能量消耗基因.
结论:
- 低FCR羊的乳液微生物群具有较高的挥发性脂肪酸和氨基酸合成能力,从而提高了源头的能量利用率.
- 由肠微生物产生的 Propionate 增强肝脏葡萄糖生成,为肌肉生长提供能量并提高料效率.
- 肠微生物群和肝脏之间的共同代谢是提高反动物料效率的关键决定因素.
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