边缘视觉解体和突出控制专业化是耳网络拓学的特征
Himanshu R Pandey1,2, Amit Keshri3, Neeraj Sinha1,2
1Centre of Bio-Medical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, India.
The European journal of neuroscience
|February 3, 2026
概括
主观耳 (ST) 涉及特定的大脑网络变化,而不是全球变化. 这些包括视觉,边缘和突出网络的连接性改变,与症状严重程度和焦虑有关.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 精神病学是一个精神病学.
背景情况:
- 主观性耳声 (ST) 被认为源于大规模的大脑网络重组.
- 具体涉及的大脑电路以及它们与症状严重程度的关系尚不清楚.
研究的目的:
- 为了研究与主观耳相关的精确大脑网络变化.
- 探索声严重程度,焦虑和特定网络连接模式之间的关系.
- 确定潜在的神经成像标记物,用于患者分层和针对性治疗ST.
主要方法:
- 结合静止状态fMRI (图形理论,ROI与ROI连接) 和VBM在114名参与者中 (57名ST,57名对照).
- 在15个功能网络中使用了CONN图谱中的协调50-ROI分片.
- 采用多变量建模和节点分析,控制共变量和多重比较.
主要成果:
- 在ST患者中确定了选择性的,而不是全球性的网络重组.
- 观察到左后半海马圈内整合减少,以及额头/岛屿枢纽中的分离增加.
- 在前端- salience-language-cerebellar 电路中发现过度连接,在默认模式/背部注意力路径中发现低连接.
- 较高的耳声严重程度与中部视觉/边缘一体化减少以及额头-部操作连接性增加有关.
- 与 subcallosal/cerebellar/occipito-limbic 区域的整合增加和膜连接性降低相关的更高的焦虑.
- VBM揭示了大脑特定区域的广泛白质量减少.
结论:
- 主观耳的特点是有针对性的网络重组,特别是减少中间时/视觉边缘一体化和增加局部专业化.
- 这些发现提供了强有力的证据,表明ST反映了特定的电路改变,而不是全球的大脑变化.
- 已识别的多模式,与症状相关的签名为ST的临床应用提供了可操作的电路标记.
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