血清25-基维生素D作为一个动态生物标志物,用于妊娠三季度内的孕前风险:一个回顾性病例对照研究
Feijun Hu1, Shunlan Du, Huaqing Li
1Dongyang Hospital of Wenzhou Medical University, Jinhua, China.
Medicine
|February 3, 2026
概括
在怀孕早期低血清25-基维生素D (25(OH) D) 水平与先兆子风险增加有关. 这种维生素D生物标志物显示出孕妇早期检测和干预的潜力.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 孕前症是全世界孕产妇和胎儿发病的主要原因.
- 维生素D缺乏在孕妇群体中很普遍,并与孕前症的发病有关.
- 识别产前的早期预测生物标志物对于及时管理至关重要.
研究的目的:
- 评估血清25-基维生素D (25(OH) D) 水平与产前风险之间的关联.
- 评估25(OH) D作为怀孕三季度内孕前的早期预测生物标志物的潜力.
主要方法:
- 一项追溯病例控制研究,涉及301名孕妇.
- 血清25(OH) D水平和临床数据是在怀孕早期,中期和晚期收集的.
- 统计分析包括斯皮尔曼相关性,物流回归和ROC分析.
主要成果:
- 血清25(OH) D水平与血压和蛋白尿有显著的反向关系,特别是在怀孕晚期.
- 经过对混杂因素进行调整后,降低的25OH) D水平与更高的孕前风险 (aOR=0.790) 有显著的关联.
- 早期怀孕25(OH) D水平显示出高预测准确度的先兆子 (AUC=0.969).
结论:
- 血清25(OH) D是一种可行的早期生物标志物,用于检测孕前.
- 在怀孕早期查25...OH) D水平可能使得及时进行干预,以改善母亲和胎儿的结果.
- 需要进一步的研究来证实这些发现,并探索维生素D补充的好处.
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