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Updated: Feb 4, 2026

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多omics数据揭示了类风湿性关节炎中细胞衰老相关基因的因果关联:基于汇总数据的门德尔随机化和同局部化分析

Ping Jiang1,2, Youji Jia1, Juhua Zhang3

  • 1Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Medicine
|February 3, 2026
PubMed
概括

细胞衰老是类风湿性关节炎 (RA) 发病的一个关键因素. 这项研究确定了5个与细胞衰老相关的基因 (BCL2L1,DNMT3B,ERRFI1,NEK4,RAF1) 与RA风险有因果关系,提供了潜在的治疗点.

关键词:
门德尔的随机化细胞衰老 细胞衰老基因表达的基因表达方式甲基化处理的方法蛋白质蛋白质是蛋白质蛋白质的组成部分.类风湿性关节炎 类风湿性关节炎

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