血和黑色素瘤之间的关联:使用NHANES 2017至2023年的数据:一个横截面研究
Yanan Tuo1, Junchen He, Tao Guo
1Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Medicine
|February 3, 2026
概括
暴露于可能会增加美国成年人的黑色素瘤风险. 较高的血含量与黑色素瘤风险增加31%有关,突出显示是这种癌症的潜在环境风险因素.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 黑色素瘤是全球癌症死亡的一个重要原因.
- 识别黑色素瘤风险因素对于预防疾病至关重要.
- 暴露与各种癌症有关,但其在黑色素瘤中的作用尚不清楚.
研究的目的:
- 研究美国成年人血液中含量与黑色素瘤发病率之间的关联.
- 为了确定暴露是否是黑色素瘤发展的危险因素.
主要方法:
- 使用2017-2023年国家健康和营养检查调查数据进行横截面研究.
- 分析包括平滑曲线拟合,多变量逻辑回归,子组分析和相互作用测试.
- 接收机运行特征曲线评估了血水平对黑色素瘤风险的预测准确性.
主要成果:
- 在123名患者的血液中含量和黑色素瘤之间发现了潜在的关联.
- 每增加1个单位的血含量都与31%的黑色素瘤风险增加有关 (OR 1.31 [1.09, 1.56]).
- 模型3的AUC为0.618,表明血液和其他黑色素瘤变量的联合预测值.
结论:
- 暴露于血液中的可能与美国成年公民的黑色素瘤相关.
- 可能是导致黑色素瘤发展的环境风险因素.
- 需要进一步的前性研究来证实这些发现.
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