AISI与腹部肥胖患者死亡率之间的关联:一个队列研究
Qingmei Niu1, Junkang Zhao2, Yatian Jia1
1Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, China.
Medicine
|February 3, 2026
概括
系统性炎症总指数 (AISI) 水平的升高与腹部肥胖患者的死亡风险更高有关. 这一发现突出了AISI的发现.
科学领域:
- 心血管健康和炎症标志物
- 公共卫生和流行病学
- 生物统计学和生存分析
背景情况:
- 腹部肥胖是增加死亡率的重要危险因素.
- 确定可靠的生物标志物来预测肥胖个体的死亡率对于有针对性的干预措施至关重要.
- 系统性炎症在肥胖相关并发症的病理生理学中起着关键作用.
研究的目的:
- 调查系统性炎症总指数 (AISI) 与腹部肥胖成年人全因死亡率之间的关联.
- 评估AISI作为该人口死亡风险分层的预后指标的潜力.
- 为患有腹部肥胖的高风险个体提供早期识别和干预策略的科学基础.
主要方法:
- 利用了1999-2016年国家健康和营养检查调查 (NHANES) 的数据,其中包括15839名患有腹部肥胖的成年参与者.
- 使用中性细胞,血小板,单细胞和淋巴细胞计数计算的AISI.
- 采用Kaplan-Meier生存分析,加权的Cox比例危险回归,子组分层和受限制的立方支线建模,并通过2019年12月31日跟踪死亡率.
主要成果:
- 在患有腹部肥胖的人群中,较高的AISI水平和所有原因死亡风险增加之间发现了统计学上显著的积极关联.
- 每增加1个单位的AISI与1%更高的死亡风险相关 (完全调整的HR=1.01).
- 高AISI组的人与低AISI组相比,死亡风险增加了16% (完全调整的HR=1.16),证实了线性关系.
结论:
- 增加的AISI水平是腹部肥胖成年人死亡风险增加的重要独立预测因素.
- 该AISI作为一个有价值的预后指标,用于高风险人群的死亡率.
- 将AISI整合到临床评估中可以加强监测策略,以识别和管理处于风险中的个人.
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