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在泌尿动力学研究后开发和验证用于预测尿路感染的诺米克图
Omri Schwarztuch Gildor1,2, Elad Yosef1,2, Netanel Levin1,2
1Department of Urology, Meir Medical Center, Kfar-Saba, Israel.
Neurourology and urodynamics
|February 3, 2026
概括
一种新型的nomogram可以在尿动力学研究 (UDS) 后使用五个常见变量预测尿路感染 (UTIs). 该工具有助于选择性抗生素预防,减少低风险患者不必要使用抗生素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染病流行病学 传染病流行病学
背景情况:
- 在尿动力学研究之前的抗生素预防缺乏国际指导方针共识.
- 尿路感染 (UTI) 是尿动力学研究 (UDS) 的潜在并发症.
研究的目的:
- 开发和验证一个预测UDS后尿路感染风险的诺米克图.
- 根据预测的风险,评估选择性抗生素预防 (AP) 的临床净益.
主要方法:
- 多变量后勤回归用于识别尿路感染预测因子.
- 开发一个易于使用的,包含五个临床变量的名录.
- 使用ROC-AUC,Brier分数,校准和精确回忆AUC进行性能评估.
- 决策曲线分析以评估临床净益.
主要成果:
- 诺莫图包括水,神经性下尿路功能障碍,空气后残留体积≥200毫升,年龄≥70岁和导管使用.
- 命名图表显示了公平的歧视 (ROC AUC 0.7086) 和良好的整体准确性 (Brier 0.0180).
- 决策曲线分析显示,在低临床值 (<5%) 选择性AP的净益为正值.
结论:
- 一个简单的,精心校准的名图提供了个性化的UDS后尿路感染风险估计.
- 诺米图支持针对高风险患者的针对性AP,可能减少不必要的抗生素使用.
- 为了更广泛的适用性,建议进行外部验证.
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