益生菌作为减轻糖化作用的策略:对高级糖化最终产品相关疾病的机制和菌株特异性影响
Arbab Husain1, Afreen Khanam1, Hamda Khan2
1Department of Biotechnology and Life Sciences, Faculty of Sciences, Mangalayatan University, Aligarh, Uttar Pradesh, India.
Journal of food science
|February 3, 2026
概括
益生菌在与先进的糖化最终产品 (AGEs) 相关的慢性疾病的治疗方面表现有前途. 这些有益的细菌可以通过改善肠道健康和减少炎症来减少AGE,提供一种自然干预策略.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 预防医学 预防医学
背景情况:
- 糖化导致高级糖化最终产品 (AGEs),导致糖尿病和心血管疾病等慢性疾病.
- 益生菌越来越被认为具有抵消与糖化相关的代谢并发症的潜力.
研究的目的:
- 探索益生菌减轻糖化作用的机制.
- 评估益生菌和富含益生菌的食物在管理糖化相关疾病中的作用.
- 确定益生菌疗法的未来方向,以对抗慢性退行性疾病.
主要方法:
- 审查有关益生菌,糖化和慢性疾病的现有文献.
- 分析益生菌的菌株特异性影响,如乳酸菌植物菌,Bifidobacterium longum,Akkermansia muciniphila和Faecalibacterium prausnitzii. 这类益生菌.
- 评估富含益生菌的发酵食品对肠道健康和免疫调节的影响.
主要成果:
- 益生菌可以减少氧化压力,中和反应性碳类物种 (RCS),并恢复肠道微生物群平衡.
- 这些行动可能有助于减轻AGE积累和全身炎症.
- 益生菌直接缓解AGE的人类临床证据仍在出现,但潜力显著.
结论:
- 益生菌为糖化驱动的慢性疾病提供了一个有希望的,安全的,易于获得的干预措施.
- 菌株特异性效应和个性化疗法对于优化益生菌效益至关重要.
- 需要进一步的研究,包括大规模的临床验证和先进的输送系统,才能充分利用益生菌的潜力.
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