为其抗菌膜活性而制备和评估含有亚齐思罗米的奇托桑纳米颗粒
Chandana R1, Ashvini H M1,2
1Research scholar, Department of Pharmaceutics, Mallige College of Pharmacy, Bangalore, Karnataka, India.
含有阿齐思罗米辛的奇托桑纳米颗粒 (AZM-CSNPs) 显示出增强的抗微生物和抗菌膜活性. 这种新型的纳米载体系统有效地对抗金黄色葡萄球菌感染,并解决抗生素耐药性的问题.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 抗生素耐药性和与生物膜相关的感染带来了重大的临床挑战.
- 传统的阿兹罗米辛输送可能在有效性和有针对性的作用方面存在局限性.
研究的目的:
- 为改善抗微生物和抗菌膜性质,制定和评估含有阿齐思罗素的奇托桑纳米颗粒 (AZM-CSNPs).
- 开发一种稳定和有效的纳米载体系统,用于阿齐思罗米辛的输送.
主要方法:
- 纳米颗粒通过酸盐与TPP的离子凝制备,其次是PAA涂层和EDC交联.
- 物理化学表征包括粒子大小,PDI,泽塔潜力和捕获效率.
- 进行了针对金黄色葡萄球菌的体外抗菌和抗菌膜测定.
主要成果:
- 优化AZM-CSNP (CNP 1) 的粒子大小为287.3nm,PDI为0.352,泽塔电位为-22.0mV,捕获效率为98.35%.
- 在24小时内观察到90%的持续药物释放.
- 证明了增强的抗微生物活性 (17-21毫米的抑制区域) 和显著的抗菌膜活性 (71%的抑制).
结论:
- 与自由阿齐思罗米辛相比,AZM-CSNP具有更高的抗微生物和抗菌膜疗效.
- 开发的纳米载体系统对治疗生物膜相关感染和对抗抗生素耐药性充满希望.
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