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在ADA方法开发中减轻先前存在的免疫性.

Jihua Chen1, Henry Zhao1, Chris Gardner1

  • 1Bioanalytical Development, Alexion Pharmaceuticals, AstraZeneca Rare Disease, New Haven, CT, USA.

Bioanalysis
|February 3, 2026
PubMed
概括

在患者中存在的免疫反应性可能会挑战对生物疗法的抗药抗体 (ADA) 试验的开发. 一种经过修改的ADA试验有效地减轻了这种干扰,确保了可靠的免疫性评估.

关键词:
在 ADA 测试中,切割点是 ADA 测试的切割点.预先存在的反应性.抗药抗体 (ADA) 是一种抗药抗体.免疫性 免疫性 免疫性治疗增强的ADA反应治疗出现的ADA反应反应.

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