肠-大脑轴在健康和脑疾病中的作用
Oluwatayo Israel Olasunkanmi1,2,3,4, Luqi Zheng5, Peng Zheng1,2,3
1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chinese medical journal
|February 3, 2026
概括
肠-大脑轴将肠道微生物与大脑健康联系起来,影响情绪和认知. 失生症 (微生物失衡) 与神经退行性疾病有关,突出显示了治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴是一个双向通信网络,涉及神经,内分泌和免疫系统.
- 肠道微生物群的代谢物显著影响大脑功能和恒常性.
- 微生物失衡 (失生症) 与神经精神和神经退行性疾病有关.
研究的目的:
- 审查肠-大脑轴的机械基础.
- 探索饮食对肠道微生物群和大脑健康的影响.
- 讨论针对肠-大脑轴的新兴治疗策略.
主要方法:
- 对机械信号通路 (代谢,免疫,神经内分泌) 的审查.
- 分析饮食成分 (纤维,多,发酵食品) 以及它们对肠道微生物群的影响.
- 治疗干预措施的检查 (益生菌,益生菌,便微生物群移植).
主要成果:
- 代谢,免疫和神经内分泌信号是肠-大脑轴的关键媒介.
- 饮食干预调节肠道微生物群的组成和功能,影响大脑健康.
- 失生症与抑郁症,阿尔茨海默氏症和帕金森病有关.
结论:
- 肠-大脑轴是一个动态的接口,影响神经和精神病的结果.
- 对肠道微生物群的饮食调节为维持大脑健康提供了一个有希望的途径.
- 对肠道微生物群的有针对性的干预措施代表了对大脑疾病的潜在治疗策略.
更多相关视频
09:06Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
12.6K
06:19Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model
Published on: October 20, 2023
2.9K
相关概念视频
Physiology of Enteric Nervous System and Gut Health
981
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
981
Hypothalamic-Pituitary Axis
66.1K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.1K
Brain Waves
4.1K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.1K
Organization of the Brain
2.7K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.7K
Brain Imaging
743
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
743
Perpendicular-Axis Theorem
4.6K
The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
4.6K
