奎尔素对基托的可能不良影响的改善潜力
Hosny Ibrahim1, Esraa Bahgat Shehata Afifi1, Azza A A Galal1
1Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Open veterinary journal
|February 3, 2026
概括
奥梅普拉和奎尔丁显著降低了基 (KP) 对大鼠肝脏和脏功能的不良影响. 这些药物还可以减轻KP诱导的氧化损伤,提供保护性益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 烯 (KP) 是一种非类固醇抗炎药物,用于肌肉骨损伤,关节炎和痛风.
- 使用KP与对胃,肝脏和脏的不良影响有关.
研究的目的:
- 在大鼠中研究奥梅普拉和奎尔素对烯诱导毒性的保护作用.
- 评估梅和奎尔丁对肝脏和功能以及氧化应激标志物的影响.
主要方法:
- 鼠被分为四组:对照组,只有基托 (KP),奥梅普拉+KP,以及奎尔丁+KP.
- 评估胃参数 (体积,pH,),血清生物化学标志物 (肝脏和脏功能),以及胃,肝脏和脏组织中的氧化剂/抗氧化剂状态.
主要成果:
- 奥梅普拉和奎尔丁在经过KP改变的肝脏和功能测试中显示出显著的改善作用.
- KP的使用诱导了显著的氧化损伤,这种损伤在与梅或奎尔丁的同时使用时得到了显著的改善.
结论:
- 奥梅普拉和奎尔丁可以减轻罗对胃肠道,肝脏和脏的不良影响.
- 建议在凯托治疗期间同时服用奥梅普拉或奎尔塞丁,以减少其毒性.
相关概念视频
Local Anesthetics: Adverse Effects
801
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
801
Skeletal Muscle Relaxants: Adverse Effects
824
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
824
Insulin: Dosing Regimen and Adverse Effects
779
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
779
Potential Energy
42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
Standard Electrode Potentials
50.3K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.3K
Cell Potential and Free Energy
46.5K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.5K


