草根提取物改善了暴露于乙烯糖醇的老鼠的肝功能标志物和血液学参数
Weam I Al-Noqair1, Sawsan A Omer1, Promy Virk1
1Department of Zoology, College of Science, King Saud University , Riyadh, Saudi Arabia.
Open veterinary journal
|February 3, 2026
概括
草根提取物在老鼠中显示出对乙烯基醇毒性的保护作用. 这种天然化合物改善了血液学,生物化学和组织病理学标记,表明器官损伤减少.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 乙烯糖醇 (EG) 是一种常见的工业溶剂和防剂.
- 意外摄入EG可以导致严重的毒性和死亡,特别是在儿童和物中.
- 了解防治EG毒性的防护剂对于公众健康和安全至关重要.
研究的目的:
- 调查Alcea rosea根提取物对暴露于乙烯糖醇毒性的老鼠的改善作用.
- 评估天然化合物在减轻化学诱导器官损伤方面的潜力.
主要方法:
- 40只雄性Wistar大鼠被分为五组:对照组,EG暴露组和EG暴露组与Alcea rosea提取物.
- 动物在28天内暴露在乙烯基醇 (0.4%或0.75%v/v) 中.
- 在血液和组织样本上进行了血液学,生化学和组织病理学分析.
主要成果:
- 在暴露于EG的老鼠中,Alcea rosea提取物改善了封装体积和红细胞体数.
- 和肝功能标志物 (血尿素,肌素,尿酸,AST,ALT) 显示在阿尔西亚治疗中得到改善.
- 组织病理学检查显示,用Alcea rosea提取物治疗的老鼠的脏和肝脏损伤减少.
结论:
- 草根的乙醇提取物对老鼠的乙烯基醇毒性表现出显著的改善作用.
- 提取物对血液学,生化学和组织病理学参数产生了积极的影响.
- 藻显示出作为一种保护剂的承诺,防止乙烯基醇诱导的器官损伤.
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