患病率,多区域血管分布,以及在牛皮中亚临床动脉样硬化的负担:EDSAP研究
Carlota Abbad-Jaime de Aragon1, Emilio Berna-Rico1, Alba Lecumberri1
1Department of Dermatology, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
JAAD international
|February 3, 2026
概括
牛皮患者在多个血管区域的早期动脉样硬化率高. 心血管风险得分往往低估了这种亚临床动脉样硬化 (SA) 风险.
科学领域:
- 心血管成像 - 心血管成像
- 皮肤病学 皮肤病学
- 血管生物学 血管生物学
背景情况:
- 牛皮与由于慢性炎症而增加动脉样硬化风险有关.
- 之前关于牛皮的亚临床动脉样硬化 (SA) 的研究集中在单个血管区域.
研究的目的:
- 综合评估使用成像技术在牛皮患者中多地SA流行率.
- 确定SA和已确定的心血管 (CV) 风险得分之间的关系.
主要方法:
- 评估了120名患有中度至重度牛皮的患者,并且以前没有心血管疾病.
- 进行了动脉/大腿动脉的血管超声波和冠状动脉CT血管造影.
- SA被定义为斑块存在或冠状动脉分数≥1.1.
主要成果:
- 77%的参与者表现出SA,大腿动脉受到影响最大 (57.1%).
- 腿部斑块显示出与冠状动脉样硬化参数的强烈关联.
- 心血管风险得分显著低估了低风险和中等风险个体中的SA患病率.
结论:
- 这项研究提出了第一项多地SA评估牛皮,表明早期疾病的高患病率.
- 股骨动脉参与与冠状动脉样硬化相关,突出显示系统性血管问题.
- 目前的心血管风险得分可能需要重新校准,以便在牛皮患者中有效预防SA.
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