婴儿PPI使用的治疗困境 - - 不再是一个困境
Simran Aggarwal1, Michael Rieder2
1Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Paediatrics & child health
|February 3, 2026
概括
质子抑制剂 (PPI) 对婴儿逆流益处的证据有限,这引发了人们对感染和营养吸收的担忧. 指南建议采用非药物方法,但PPI在婴儿中仍然很常见.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 质子抑制剂 (PPI) 经常用于成人和老年儿童的胃食道逆流性疾病 (GERD).
- 婴儿GERD管理指南优先考虑非药物干预措施.
- 婴儿PPI的疗效和安全性并未通过可靠的临床试验得到充分证实.
研究的目的:
- 评估PPI在婴儿群体中有争议的使用情况.
- 审查支持PPI在患有反流的婴儿中使用的证据.
- 要突出与婴儿PPI使用相关的潜在不良影响.
主要方法:
- 对儿科群体的PPI现有文献的审查,重点是婴儿.
- 对婴儿反流管理当前临床指南的分析.
- 对 PPI 治疗的婴儿报告的不良事件和益处的评估.
主要成果:
- 很少有经过良好控制的研究表明,PPI对婴儿有明显的益处.
- 有关使用PPE增加感染 (胃肠道,呼吸道) 风险的担忧.
- 潜在的营养吸收不良和婴儿肠道微生物群的变化.
结论:
- 目前的证据并不强烈支持在婴儿中常规使用PPI.
- 非药物管理仍然是婴儿反流的推第一线治疗方法.
- 尽管有指导方针,但PPI经常被处方给婴儿,需要仔细考虑风险和益处.
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