德图穆马布与听力障碍之间的关联:一个元分析
Maxim J Barnett1, Maria deMelo1, Maria Rego1
1Internal Medicine, Jefferson Einstein Philadelphia Hospital, Philadelphia, USA.
Cureus
|February 3, 2026
概括
甲状腺眼病治疗teprotumumab与较高的听力损失风险有关. 这一关联在随机对照试验和观察性研究中一致,表明存在重大安全问题.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 甲状腺眼病 (TED) 是一种使人虚弱的自身免疫性疾病.
- 原是FDA批准的TED治疗方法,向IGF-1R通路.
- 新出现的证据表明,teprotumumab与听力障碍之间存在潜在的关联.
研究的目的:
- 系统地审查和综合证据,以TED患者使用teprotumumab相关的听力损失的风险.
- 在不同的研究设计中,使用广泛和严格的定义量化听力损失的风险.
主要方法:
- 在MEDLINE和CINHAL进行了全面的文献搜索,截至2025年9月20日.
- 包括的研究包括四项随机对照试验 (RCT) 和五项观察性研究.
- 进行了元分析,以计算听力损失的风险比率 (RR).
主要成果:
- 在RCT (广义:RR 3.57;严格:RR 5.23) 和观察性研究 (广义:RR 2.78;严格:RR 2.76) 中,使用teprotumumab与有统计学意义的听力损伤风险增加有关.
- 结果在敏感性分析中仍然显著,没有证据表明异质性或出版偏差.
- 无论使用什么听力障碍的定义,这种关联都是一致的.
结论:
- 在患有甲状腺眼病的患者中,teprotumumab与听力损失的风险增加显著相关.
- 这种风险在各种研究设计和听力损失的定义中很明显.
- 需要进一步的研究来探索管理策略,复发和听力功能的恢复.
关键词:
我们的外外体 (exophthalmos) 是一个外体.坟墓的轨道病变 - 坟墓的轨道病变这里是特佩兹塔 (Tepezza).这就是为什么teprotumumab.甲状腺眼睛疾病 甲状腺眼睛疾病更多相关视频
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