富含益生菌的酸奶可以帮助预防人类结肠直肠癌吗?
1Department of Medicine, University of Louisville School of Medicine, 600 Marshall Street, Louisville, KY, 40202, USA.
Cancer pathogenesis and therapy
|February 3, 2026
概括
含有丰富益生菌的酸奶消费,如Bifidobacterium,可能显著降低结直肠癌的风险. 这些益生菌有助于调节肠道健康,减少炎症,并防止瘤发展.
科学领域:
- 胃肠道学和营养学
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
背景情况:
- 结肠直肠癌 (CRC) 仍然是一个重大的全球健康问题.
- 肠道微生物群失调和慢性炎症都与CRC病变产生有关.
- 包括发酵食品在内的饮食干预措施正在探索癌症预防.
研究的目的:
- 调查酸奶消费与结直肠癌风险之间的关联.
- 阐明益生菌,特别是Bifidobacterium,影响CRC发展的机制.
- 确定加强CRC预防的战略.
主要方法:
- 流行病学分析将酸奶摄入量与CRC发病率相关联.
- 在体外和体内研究检查Bifidobacterium菌株对癌细胞系和瘤模型的影响.
- 对肠道微生物群组成和炎症标志物的分析.
主要成果:
- 酸奶消费与20-40%的CRC风险降低有关,特别是在靠近结肠的瘤中.
- 肠道中高水平的Bifidobacterium与这种保护作用相关.
- 益生菌调节肠道微生物群,减少炎症,并产生保护癌症的代谢物.
- 双杆菌菌株调节了参与瘤抑制的信号传递和免疫通路.
结论:
- 定期食用酸奶可能是预防结肠直肠癌的可行策略.
- 益生菌,特别是Bifidobacterium,在通过肠道调节缓解CRC发展方面发挥着至关重要的作用.
- 建议包括更早的癌症查和增加饮食纤维摄入量以预防.
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