在功能衰竭中Pregabalin毒性:一种药物错误具有神经后果
Adam G Selway1,2, Shea Roffey2, Anthony F Brown1,2
1Faculty of Medicine, University of Queensland, Brisbane, AUS.
Cureus
|February 3, 2026
概括
一个药物错误导致了严重的普雷加巴林毒性在透析依赖的病人. 血液透析有效地治疗了毒性,突出显示了对脏衰竭患者药物的仔细审查的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 临床毒理学 临床毒理学
背景情况:
- 普雷加巴林是一种 gabapentinoid 药物,通常用于神经病痛和发作.
- 患有功能衰竭的患者有增加药物积累和毒性的风险.
- 药物错误可能导致重大不良事件,特别是在脆弱人群中.
研究的目的:
- 在需要透析的患者中报告严重的普雷加巴林毒性病例.
- 为了突出在功能衰竭中 gabapentinoid 毒性的非典型表现.
- 强调药剂师在药物错误检测和预防方面的作用.
主要方法:
- 一个50岁的女性在透析的案例报告.
- 对临床表现,药物 anamnesis 和治疗进行审查.
- 对药物错误的分析,涉及Pregabalin剂量增加了12倍.
主要成果:
- 患者呈现出渐进的虚弱,昏迷和步态障碍.
- 血液透析成功地用于治疗.
- 毒性与社区药房发行错误有关.
结论:
- 在患有无法解释的神经症状的患者,特别是功能受损的患者中,应考虑 gabapentinoid 毒性.
- 对于患有功能衰竭的患者来说,警的药物调节对于预防不良药物事件至关重要.
- 急诊室药剂师在识别药物错误和确保患者安全方面发挥着至关重要的作用.
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