邻居显微体与儿童遗传风险之间的相互作用 持续的痛苦 精神病类经历
Yinxian Chen1, Qingyue Yuan2,3, Lina Dimitrov1
1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Nature. Mental health
|February 3, 2026
概括
邻居暴露,而不是遗传风险,在儿童中显著预测了持续的令人痛苦的精神病类经历 (PLE). 基因与环境的相互作用表明,有害的邻居因素可能会影响具有较低遗传倾向的儿童.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 遗传学和基因组学 遗传学和基因组学
- 环境流行病学环境流行病学
背景情况:
- 不同的人群中持续痛苦的精神病类经历 (PLE) 的遗传风险仍未得到充分研究.
- 遗传因素和邻居环境在持续痛苦的PLE中的相互作用在很大程度上是未知的.
研究的目的:
- 在一个多祖先的队列中调查持续的痛苦PLE的遗传风险.
- 检查与持续的痛苦PLE相关的基因邻居环境相互作用.
主要方法:
- 利用了6449名青少年大脑和认知发展研究参与者的数据.
- 使用多祖先精神分裂症多基因风险评分 (SCZ-PRS) 评估遗传风险.
- 量化了社区层面的曝光,以创建一个社区曝光组 (NE) 评分.
主要成果:
- 精神分裂症多原风险评分 (SCZ-PRS) 显示,与持续的痛苦PLE没有显著的关联.
- 邻居暴露组 (NE) 评分与持续痛苦PLE (OR = 1.15,P = 0.003) 的几率增加有显著关联.
- 在SCZ-PRS和NE之间观察到显著的负乘法相互作用 (P = 0.039).
结论:
- 有害的邻居暴露可能会导致来自多祖先人口的儿童持续痛苦的PLE.
- 基因风险较低的儿童可能特别容易受到邻里不利的环境影响.
- 研究结果突出了遗传和环境风险的病因作用,并确定了干预的目标.
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