一个不寻常的诱导的神经发育性糖尿病无味症病例
Venkateshwara Reddy Malreddy1, Laxmi M Balmuri2
1Internal Medicine, Manchester Royal Infirmary, Manchester, GBR.
Cureus
|February 3, 2026
概括
本案例研究详细介绍了一名患有双相情感障碍的患者,他经历了混乱和腹痛,最初接受了败血症和高血糖症的治疗. 的重新启动导致了原性糖尿病无味症 (NDI),用利尿剂进行管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 是双相情感障碍的基石治疗,但具有毒性风险.
- 超性高血糖状态 (HHS) 和诱导的原性糖尿病无味症 (NDI) 可以呈现类似的症状,如多尿症和电解质障碍.
- 区分这些情况对于适当的管理和预防并发症至关重要.
研究的目的:
- 报告一个患有双相情感障碍的患者在治疗中的病例,该病例开发了NDI.
- 要突出诊断在区分HHS诱导的透性尿液与诱导的NDI的挑战.
- 强调在治疗多尿和电解质失衡的患者中考虑NDI的重要性.
主要方法:
- 一个53岁患有双相情感障碍的女性在治疗中的病例报告.
- 怀疑尿道败血症,HHS和急性损伤的初始管理.
- 糖尿病无味症的诊断工作,包括血清和尿液度,co-peptin水平和desmopressin挑战.
- 对于已确认的NDI,使用 thiazide 尿剂进行治疗.
主要成果:
- 患者最初出现了暗示尿道败血症和HHS的症状,高血糖和急性损伤.
- 在重新开始治疗后,她出现了多尿症,严重的高血症和血清度升高,与NDI一致.
- NDI的诊断得到了中央DI的排除和对 thiazide 利尿剂的反应的支持.
- thiazide 利尿剂改善了尿液输出,稳定了血清水平.
结论:
- 疗法可能会导致NDI,当与诸如HHS等疾病同时发生时,这会构成诊断挑战.
- 临床怀疑NDI对于治疗的多尿和电解质障碍患者至关重要.
- 及时诊断和管理,包括利尿剂治疗和断,对于NDI患者至关重要.
相关概念视频
Unusual Results
3.8K
Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ from the mean, μ is considered unusual.
Maximum unusual value =...
According to the range rule of thumb, any value above or below two standard deviations, 2σ from the mean, μ is considered unusual.
Maximum unusual value =...
3.8K
z Scores and Unusual Values
11.0K
The z score is one of the three measures of relative standing. It describes the location of a value in a dataset relative to the mean. z scores are obtained after the standardization of the values in a dataset. The z score for the mean is 0.
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
11.0K
Pathophysiology of Diabetes
3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Diabetes: Management and Pharmacotherapy
1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
Psychoneuroimmunology: Diabetes and Cancer
500
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
500
Diabetes Mellitus: Type 2 and Gestational
5.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K


