心肌细胞中的circRNA调节的编程细胞死亡网络:分子交叉声和治疗翻译
Wenhua Jiang1,2, Yuetong Li3, Zhenxiong Liu2
1Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Non-coding RNA research
|February 3, 2026
概括
循环RNAs (circRNAs) 调节心血管疾病 (CVD) 中的编程细胞死亡 (PCD). 这篇评论强调了circRNAs作为潜在的心脏病诊断和治疗点.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 心血管疾病 (CVD) 是全球主要的健康问题.
- 编程细胞死亡 (PCD) 途径在心肌损伤中至关重要.
- 循环RNAs (circRNAs) 是心肌细胞命运的新兴调节者.
研究的目的:
- 审查circRNAs在心血管疾病中调节PCD中的作用.
- 探索基于circRNA的CVD诊断和治疗方法.
- 讨论 circRNA 研究的未来临床翻译策略.
主要方法:
- 文献综述综合了目前关于心血管疾病中circRNAs和PCD的研究.
- 分析circRNA机制,包括分子海绵,蛋白相互作用和表观遗传调节.
- 评估circRNAs的诊断和治疗应用.
主要成果:
- 循环RNAs作为多个PCD途径 (ferroptosis,apoptosis,pyroptosis,自,necroptosis) 在心脏中的关键调节者.
- 循环RNA表达模式可以用于高精度的CVD分层.
- 通过病毒载体传递的保护性circRNAs在心肌梗塞的临床前模型中显示出有效性.
- 基于CRISPR的编辑和纳米平台显示出基于circRNA的治疗方法的前景.
结论:
- 循环RNA网络代表了对心血管疾病有前途的治疗目标.
- 取决于上下文的circRNA功能和路径交叉需要进一步调查.
- 组织特异性传递仍然是circRNA疗法的临床转化的一个挑战.
相关概念视频
01:29Translational Regulation
614
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
614
01:23Negative Regulator Molecules
38.5K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.5K
02:26Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
01:18Autophagic Cell Death
4.5K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.5K
01:30Overview of Cell Death
9.9K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.9K
02:07Improving Translational Accuracy
14.9K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.9K