在右侧和左侧结肠癌中中切除后瘤结果的比较
1Department of General Surgery/Surgical Oncology, Mersin University Faculty of Medicine, Mersin, Turkey.
Nigerian journal of clinical practice
|February 3, 2026
概括
与左侧结肠癌 (LCC) 相比,右侧结肠癌 (RCC) 呈现出更具侵略性的特征和更差的生存结果. 瘤位置是结直肠癌患者的独立预后因素.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 新出现的证据表明,右侧结肠癌 (RCC) 和左侧结肠癌 (LCC) 之间存在明显的生物学差异.
- 在CRC中瘤侧向的预后意义仍然存在争议.
研究的目的:
- 为了比较RCC和LCC之间的临床病理特征和瘤结果.
- 为了确定经过为结肠腺癌进行美切除的患者的独立预后因素.
主要方法:
- 对948名结肠腺癌患者进行治疗切除的回顾性队列研究 (2010-2020年).
- 被归类为RCC (n=335) 或LCC (n=613) 的患者.
- 对人口统计,病理和生存数据 (总生存率,无疾病生存率) 的分析,使用Cox回归来确定预后因素.
主要成果:
- RCC患者年龄较大,女性更频繁,并呈现出更具侵略性的瘤特征 (差差分化,T阶段晚期,KRAS突变更高).
- 与LCC相比,RCC表现出较低的整体存活率 (79.1%与85.0%) 和无病存活率 (74.0%与78.0%).
- 多变量分析确定了右侧瘤位置作为一个独立的不良预后因素 (HR=1.45,P=0.024).
结论:
- 右侧结肠癌表现出比左侧结肠癌更具侵略性的特征和更糟糕的生存结果.
- 瘤侧向是结直肠癌的独立预后因素.
- 这些发现强调了在CRC管理和预后中考虑瘤位置的重要性.
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