高果糖消费可能会增加5-甲 - - 诱导心脏毒性
A Kuyumcu1, M Yıldız1, S Ulusan2
1Department of Nutrition and Dietetics, Faculty of Health Sciences, Suleyman Demirel University, Isparta, Turkey.
Nigerian journal of clinical practice
|February 3, 2026
概括
高果糖摄入量加剧了5-甲 (5-FU) 的心脏毒性. 这项研究发现,将高果糖饮食与5-FU结合起来,在老鼠中显著增加了心脏损伤和功能障碍.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 毒理学 毒理学 毒理学
背景情况:
- 5-Fluorouracil (5-FU) 是一种广泛使用的化疗剂,具有已知的心脏毒性副作用.
- 高果糖消费与心血管病理生理学有关,可能会恶化药物诱导的毒性.
- 饮食中的果糖与5-FU心脏毒性之间的相互作用需要进一步研究.
研究的目的:
- 调查高果糖摄入量与5-Fluorouracil (5-FU) 诱导的心脏毒性之间的关系.
- 为了确定果糖摄入是否增强了5-FU对心脏的不良影响.
主要方法:
- 40只雄性Wistar白鼠被分成四组:对照组,高果糖饮食组,5-FU治疗组和5-FU+高果糖饮食组.
- 5-FU在第0天和第39天被给予150mg/kg.
- 用心声图和心电图来评估心脏功能,并对心脏毒性评估进行了他的病理学分析.
主要成果:
- 与5-FU组 (P <0.001) 相比,5-FU+高果糖饮食组的喷射分数 (11%) 和QRS间隔 (15%) 的延长以及纠正的QT间隔 (11%) 的显著减少.
- 组织病理学检查显示,与5-FU一起食高果糖饮食的老鼠心脏中的炎症细胞透,瘤溶解和亡增加 (P < 0.001).
结论:
- 高果糖消费显著增强了5-甲诱导的心脏毒性.
- 饮食干预措施,如限制果糖摄入量,可能对减轻化疗相关的心脏不良事件至关重要.
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