接受塞马格卢提德治疗的患者的胃超声波:一个前性,多中心,匹配的对照研究
Nils Vlaeminck1,2, Peter Van de Putte3, Melanie Dekeyser4
1Faculty of Medicine and Health Sciences, Department of Anaesthesiology, University of Antwerp, Antwerp, Belgium.
Anaesthesia
|February 3, 2026
概括
接受塞马格卢提德的患者在手术前胃充满的风险明显更高,增加了吸入风险. 胃超声波可以指导麻醉管理,以提高患者的安全性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 众所周知,类似葡萄糖类-1受体激动剂 (GLP-1 RAs) 像塞马格卢提德一样会延迟胃排空.
- 最近的数据表明,在接受GLP-1RA的禁食患者中,胃残留含量的风险增加.
- 之前的研究缺乏对潜在混因素的控制.
研究的目的:
- 调查塞马格卢提德对正在接受选择性手术的禁食患者胃内含量的影响.
- 为了比较Semaglutide使用者的胃超声波发现与匹配的对照组.
- 评估与西马格卢提德使用相关的外科风险.
主要方法:
- 前性,多中心,匹配的病例控制研究.
- 44名接受塞马格卢提德治疗的患者与基于年龄,BMI和糖尿病状况的对照人群进行了1:1匹配.
- 腹部超声波在仰卧和右侧部位置进行; "满腹"定义为可见固体含量或胃体积> 1.5毫升/公斤.
主要成果:
- 在49%的塞马格卢提德患者和18%的对照组 (OR4.29,p=0.003) 中观察到腹部充满.
- 固体胃部含量在塞马格卢提德使用者中明显更频繁 (42%对7%,OR9.85,p<0.001).
- 计算的胃体积在各组之间没有显著差异.
结论:
- 塞马格卢提德治疗与胃残留含量的持续升高风险有关,即使在禁食后也是如此.
- 这一发现表明肺吸气风险的潜在增加.
- 建议进行胃超声波以指导个性化麻醉管理并优化外科手术期间的安全性.
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