定期的体力活动能否在移植前和/或移植后避免与代谢功能障碍相关的脂肪性肝病及其并发症?
Theja V Channapragada1, Jonathan G Stine1,2
1Department of Medicine, Penn State Health- Milton S. Hershey Medical Center.
Current opinion in organ transplantation
|February 3, 2026
概括
在肝移植 (LT) 之前和之后,定期体力活动对与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者有益. 运动可以改善肝脏健康,胰岛素敏感性和生活质量,有助于移植候选人和康复.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 运动生理学 运动生理学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是全球肝移植 (LT) 的首要指示.
- 供体供应有限和LT后并发症需要预防策略.
- 身体活动是MASLD管理的一个关键干预措施.
研究的目的:
- 在LT之前审查身体活动在MASLD管理中的作用.
- 为了检查由于MASLD而导致晚期慢性肝病 (advCLD) 的患者体力活动的益处.
- 评估身体活动对LT后结果的影响.
主要方法:
- 流行病学和干预研究的审查.
- 对身体活动对肝脏脂肪,胰岛素敏感性和氨基转移酶的影响的分析.
- 评估体育活动对肌肉力量,表现和生活质量的影响.
主要成果:
- 身体活动减少肝脏脂肪,并改善胰岛素敏感性在非脊髓炎的MASLD,独立于体重减轻.
- 运动可以提高advCLD的身体表现和生活质量,支持移植候选人.
- 经过LT后的身体活动可能会减少心脏代谢并发症并改善恢复,但长期益处需要进一步研究.
结论:
- 将体育活动纳入临床护理对MASLD患者在LT前后的治疗至关重要.
- 需要进一步的研究来优化advCLD和后LT人群的体育活动干预措施.
- 提高这些群体的生存率和生活质量是一个重要的公共卫生优先事项.
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