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Updated: Feb 4, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
11:37

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

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动态结合剂交换提高了DNA-PAINT中的蛋白质标记效率,高达15倍

Clemens Steinek1, Isabelle Pachmayr1, Sebastian Strauss1

  • 1Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.

Angewandte Chemie (International ed. in English)
|February 3, 2026
PubMed
概括

动态绑定器交换 (DyBE) 通过使用可逆绑定器来增强目标采样,改进了DNA-PAINT超分辨率显微镜. 这种方法实现了更高的标记效率,使得蛋白质相互作用的敏感检测,如HER2同位体和EGFR-HER2异位体.

关键词:
这就是DNA-PAINT.标签 标签 标签 标签单分子成像技术 单分子成像技术空间蛋白质组学是什么意思超高分辨率的显微镜.

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