通过Irx3-Etfa通路调节铁亡,可以防止心脏缩
Bing Li1, Yaoting Zhang1, Yu Fu1
1Department of Cardiovascular Diseases, The First Hospital of Jilin University, Changchun, Jilin, China.
概括
病理性心脏缩包括铁和线粒体问题. 鉴定出Irx3-Etfa通路是关键的调节器,抑制铁亡并为心力衰竭提供潜在的治疗标.
科学领域:
- 心血管生物学 心血管生物学
- 疾病的分子机制.
- 线粒体生物学 线粒体生物学
背景情况:
- 病理性心脏缩显著导致心脏衰竭.
- 铁和线粒体功能障碍在心脏缩中很常见.
- 对这些过程的上游转录调节的理解很少.
研究的目的:
- 确定调节心脏缩,铁亡和线粒体功能障碍的转录机制.
- 研究Irx3-Etfa轴在病理性心脏缩中的作用.
- 探索针对Irx3-Etfa通路的治疗潜力.
主要方法:
- 横向大动脉收缩 (TAC) 诱导的过度缩心脏数据集的综合生物信息学分析.
- 识别与线粒体相关的差异表达基因 (MitoDEGs).
- 使用体内和体外模型进行转录因子预测和实验验证,包括腺相关病毒介导的基因操纵.
主要成果:
- 确定了Etfa作为一个由转录因子Irx3直接调节的枢纽MitoDEG,这种转录因子在过度缩的心脏中被上调调节.
- 证明Irx3-Etfa轴抑制铁亡并减弱过度缩重塑.
- 表明Irx3或Etfa的过度表达可缓解心肌细胞缩和ferroptotic损伤,而Etfa的淘汰消除了Irx3的保护作用.
结论:
- 揭示了一种新的转录途径,将线粒体代谢与心脏缩中的铁亡调节联系起来.
- 伊尔克斯3-埃特法轴在缓解病态心脏缩和铁死方面发挥着至关重要的作用.
- 伊尔克斯3-埃特法轴代表了治疗病态心脏缩和心力衰竭的有希望的治疗标.
更多相关视频
09:24O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
Published on: October 6, 2022
4.3K
08:47Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes
Published on: December 16, 2022
2.8K
相关概念视频
01:27C4 Pathway and CAM
49.2K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.2K
02:31Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
01:16Zones of Protection
798
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
798
01:23Radial System Protection
443
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
443
01:27Protecting Self-Esteem
212
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
212
01:27Line Protection with Impedance Relays
454
Coordinating time-delay overcurrent relays in complex radial systems and directional overcurrent relays in multi-source transmission loops can be challenging. Impedance relays address these issues by responding to the voltage-to-current ratio, specifically measuring the apparent impedance of a line. These relays become more sensitive during faults as current increases and voltage decreases, thereby reducing the apparent impedance.
Under normal conditions, low load currents keep the measured...
Under normal conditions, low load currents keep the measured...
454