一个多中心,为期四年的镜像研究,比较长效注射抗精神病药物在治疗双极性障碍中的有效性:来自LAICO研究的结果
Juan Antonio García-Carmona1,2,3, Joshua Barnett4, María Pilar Campos-Navarro5
1Department of Neurology, Santa Lucia University Hospital, Murcia, Spain.
Bipolar disorders
|February 3, 2026
概括
长效注射药 (LAI) 如阿里皮普拉 (A1M),瑞斯佩里 (R-LAI) 和帕利佩里棕酸 (PP1M,PP3M) 显著减少双相情感障碍 (BD) 患者的住院治疗. 与其他LAI相比,PP3M显示了增加床位使用的风险最低.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 双极性障碍 (BD) 的管理通常涉及长效注射剂 (LAI).
- 对比不同的LAI配方对于优化患者的治疗结果至关重要.
- 这项研究评估了在BD患者中服用阿里皮普拉1个月 (A1M),RISPERIDONE-LAI (R-LAI) 和PALIPERIDONE PALMITATE (PP1M,PP3M) 的情况.
研究的目的:
- 为了比较A1M,R-LAI,PP1M和PP3M在减少BD患者住院治疗的有效性.
- 分析不同LAI配方的治疗延续率和中止原因.
- 评估LAI启动对住院频率和持续时间的影响.
主要方法:
- 采用了为期四年的镜像研究设计.
- 包括开始LAI治疗的成年BD患者.
- 医院住院数据 (数量和长度) 在LAI启动前两年和之后进行了比较.
主要成果:
- 在122名患者中,有74名患者在2年内继续接受LAI治疗;停止治疗的原因包括不良遵守,无效和耐受性.
- R-LAI显示药物停用和首次住院的时间明显缩短.
- 虽然整体住院病例减少,但与PP3M相比,A1M,PP1M和R-LAI与床位使用风险增加有关. 研究完成者的入院和入床日数量显著减少.
结论:
- 长效抗精神病药物,特别是PP3M,与BD患者的高保留率和降低住院率有关.
- 与A1M,PP1M和R-LAI相比,PP3M在床上使用方面表现出了有利的安全性.
- 终止LAI治疗显著增加了住院的风险,强调了治疗坚持的重要性.
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