EXPRESS:血红蛋白与红细胞分布宽度比率和在接受大动脉置换手术的患者的术后存活率之间的相关性
Chaojun Yan1, Jie He2, Ying Li3
1Cardiac Surgery Department, Southwest Hospital, Army Medical University, Chongqing, China.
概括
血红蛋白与红细胞分布宽度比率 (HRR) 是大动脉置换后死亡率的重要预测指标. 较高的HRR与死亡风险降低有关,改善了患者的预后.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 医学统计 医学统计
背景情况:
- 血红蛋白和红细胞分布宽度 (RDW) 是关键的血液学参数.
- 他们的综合比率 (HRR) 正在重新评估心血管重要性.
- 了解HRR在前列动脉置换后 (AVR) 结果中的作用至关重要.
研究的目的:
- 评估血红蛋白与红细胞分布宽度比率 (HRR) 与大动脉置换患者的整体存活率的相关性.
- 开发和验证使用HRR对死亡风险的预测模型.
主要方法:
- 从MIMIC-IV数据库中对1976名第一次接受AVR的患者进行了回顾性分析.
- 应用单变量和多变量考克斯比例危险模型.
- 使用 ROC 曲线,校准曲线和 DCA 的名ogram 预测模型的构建和性能评估.
主要成果:
- 手术前HRR是AVR接受者的长期全因死亡率的独立预测因子.
- 每增加1个单位的HRR显著降低了死亡风险超过87%在1,3年和5年 (P <0.05).
- 诺莫格拉姆模型表现出良好的预测性能 (在培训和验证集中,AUC为0.834和0.766用于1年的预测).
结论:
- 手术前HRR是AVR后长期死亡率的强大,独立的预后标志物.
- 将HRR整合到临床风险评估中可以提高患者的预后.
- HRR可以支持为AVR接收者制定个性化的管理策略.
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