弹性前性素载体的制备和评估:缓解性结肠炎的有针对性的治疗策略
Abeer Salama1, Marwa Anwar Wagdi2, Amany A El-Fadaly1
1Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), Dokki, Cairo, Egypt.
Journal of drug targeting
|February 3, 2026
概括
氨酸有效地通过减少炎症和氧化应激来治疗性结肠炎. 这种新的药物输送系统增强了素.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 胃肠病学 胃肠病学
- 纳米技术 纳米技术
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,导致显著的氧化损伤.
- 目前对UC的治疗方法在有效性和交付方面存在局限性.
- 素是一种天然的黄类化合物,显示出潜在的治疗益处,但需要改进的输送系统.
研究的目的:
- 开发和表征新型试验性配方 (CR-Pro) 用于素 (CR) 输送.
- 评估CR-Pro在酸诱导的性结肠炎小鼠模型中的疗效.
- 评估CR-Pro作为UC治疗中增强药物输送方法的潜力.
主要方法:
- 氨酸 (CR-Pro) 用同化相分离技术制备.
- 配方的特点是捕获效率 (EE%),粒子大小 (PS) 和泽塔潜力 (ZP).
- 在UC的老鼠模型中评估了体外药物释放和体内疗效.
主要成果:
- CR-Pro表现出高的捕获效率 (94.5399.66%) 和合适的粒子大小 (133.6331.3 nm).
- 高负的泽塔电位值表明了稳定的囊泡配方.
- 在体内研究表明,CR-Pro显著降低了结肠炎症标志物 (NO,TLR4,NF-κβ) 和氧化应激,同时增加了抗氧化剂水平 (GSH,SIRT-1).
结论:
- 氨酸囊 (CR-Pro) 是一种稳定有效的氨酸药物输送系统.
- 在化学诱导的UC模型中,CR-Pro显著减轻了炎症和氧化应激.
- 这种新的配方有望提高素在性结肠炎治疗中的治疗效果.
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