逆行式喉功能障碍:澳大利亚患者的特征和结果
Zhou Hao Leong1, Sarah Emmett1, Katrina Sandham1
1University of Sydney Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
ANZ journal of surgery
|February 3, 2026
概括
毒素A注射有效治疗逆行式喉功能障碍 (RCPD),年轻患者和全身麻醉与更好的结果相关. 这项研究分析了109名RCPD患者,这些患者接受了Botulinum A毒素 (BonT-A) 治疗.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 神经学 神经学
背景情况:
- 逆行式喉功能障碍 (RCPD) 是一种以无法吐为特征的疾病.
- 目前对RCPD的第一线治疗包括注射肉毒素A毒素 (BonT-A) 进入喉肌肉.
- 了解治疗结果和患者因素对于优化RCPD管理至关重要.
研究的目的:
- 评估玻尿酸A毒素 (BonT-A) 注射在治疗逆行性喉功能障碍 (RCPD) 的疗效.
- 确定与成功RCPD结果相关的患者人口统计和治疗参数.
- 评估短期和长期随访时的症状缓解率.
主要方法:
- 在2018年1月至2024年11月期间,对109名被诊断患有RCPD的患者进行了回顾性图表审查.
- 数据收集包括人口统计,临床信息和使用RCPD-Q问卷 (2021年底开始) 的症状得分.
- 分析 BonT-A 初始注射后治疗结果,随访时间为 4 周和 >3 个月.
主要成果:
- 在109名患者中,56.9%是女性,平均年龄为30.0岁.
- 在74名患者的初始治疗中,4周后71.6%的患者显示症状完全消失.
- 在 >3个月的随访期,30名患者中有56.7%报告完全康复,而33.3%的患者没有康复或症状逆转.
结论:
- 玻尿酸A毒素 (BonT-A) 注射在管理逆行性喉功能障碍 (RCPD) 中显示出显著的有效性.
- 与成功治疗结果积极相关的因素包括较年轻的患者年龄,在全身麻醉下施用,以及较高的BonT-A剂量.
- 虽然短期解决率很高,但长期症状持续或复发需要进一步调查和管理策略.
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