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惠普尔病:其他皮肤病中的泛炎. 一个案例报告和文献综述
Alfonso Agüera-Sánchez1,2, María Del Carmen Brufau-Redondo2,3, Enrique Poblet1,2
1Pathology Department, Hospital General Universitario Reina Sofía, Murcia, Spain.
Journal of cutaneous pathology
|February 3, 2026
概括
惠普尔病 (WD) 可以表现为泛肠炎,一种罕见的皮肤炎症. 识别这种皮肤标志对于诊断这种由Tropheryma whipplei引起的罕见传染病至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 惠普尔病 (WD) 是一种罕见的全身性感染,主要影响胃肠道.
- 皮肤上WD的表现往往被忽视,但可以在诊断上具有重要意义.
- 对治疗无反应的多关节炎可能会在其他WD症状之前出现.
研究的目的:
- 突出泛炎作为一种特定的,虽然罕见的,威普尔病的皮肤病学表现.
- 通过泛肠炎诊断出WD病例并随后确认.
- 审查有关WD相关的胰腺炎的文献,并强调其未得到充分承认.
主要方法:
- 一个54岁的男性患有耐火性多关节炎和皮下结节的病例报告.
- 皮肤病变的组织病理学分析显示 septal panniculitis 与泡性巨细胞.
- 通过使用电子显微镜和PCR的十二指肠活检确认Tropheryma whipplei感染.
主要成果:
- 这名患者出现了泛肠炎,其特征是皮下细菌体加厚和泡性巨细胞.
- 组织病理学显示没有血管炎,使其与其他类型的泛炎不同.
- 文献审查发现了15例额外的WD相关的泛炎病例,表明诊断不足.
结论:
- 胰腺炎是惠普尔病的高度特定的皮肤发现.
- 皮肤学检查和活检对于诊断WD至关重要,特别是当胃肠道症状不存在或异常时.
- 提高人们对WD相关的泛炎的认识,可以提高这种罕见传染病的诊断率.
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