单细胞分析确定了ATC类细胞,在复发的卵泡性甲状腺癌中推动了进展
Jian Chen1, Lei Xu1, Tian-Yu Liu2
1Department of Thyroid and Hernia Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Endocrinology
|February 3, 2026
概括
毛囊性甲状腺癌 (FTC) 通过不同的途径进展,复发的FTC含有侵略性的"ATC类细胞". 这些细胞中的高UBE2C表达驱动FTC生长,并暗示了一个新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 毛囊性甲状腺癌 (FTC) 呈现出早期的转移,并且预后比乳头性甲状腺癌 (PTC) 差.
- 了解FTC进展和转变为厌塑性甲状腺癌 (ATC) 对改善患者的治疗结果至关重要.
研究的目的:
- 阐明推动FTC向ATC的进展和脱差的细胞和分子机制.
- 为了识别新的生物标志物和治疗点,攻击性甲状腺癌.
主要方法:
- 从PTC,毛囊变异PTC (FVPTC),复发FTC (RFTC) 和ATC的46,739个细胞的单细胞RNA测序 (scRNA-seq).
- 生物信息分析重建甲状腺癌进展轨迹.
- 在体外和体外对已识别的标记物和途径的功能验证.
主要成果:
- 确定了从PTC,FVPTC和FTC到ATC的独特但融合的脱差路径.
- 一个新的集群.
- 类似于ATC的细胞
- 在RFTC中发现了表现出ATC特征的机器.
- UBE2C被确定为这些ATC类细胞的特定标记物,在FTC上调并与不良结果相关.
- UBE2C促进FTC增殖,瘤生长,并调节关键的代谢途径.
结论:
- 以前未被识别的UBE2C高的ATC类细胞种群有助于FTC进展.
- UBE2C是攻击性FTC的潜在生物标志物,也是一个有前途的治疗点.
- 了解这些细胞动态,可以了解甲状腺癌的演变和治疗策略.
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